Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation
Identifieur interne : 000261 ( Main/Exploration ); précédent : 000260; suivant : 000262Indium-111-labelled cationic complexes of aminothiols: structure-activity correlation
Auteurs : RBID : ISTEX:259_1993_Article_BF00169805.pdfEnglish descriptors
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Abstract
In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. A system of one six-membered and two five-membered rings, formed by the metal and the donor atoms of the ligand, may constitute a basic structure for the development of new indium tracers with myocardial affinity.
DOI: 10.1007/BF00169805
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Varvarigou</name><affiliation wicri:level="1"><mods:affiliation>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki</wicri:regionArea><wicri:noRegion>Attiki</wicri:noRegion></affiliation></author><author><name>M. Papadopoulos</name><affiliation wicri:level="1"><mods:affiliation>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki</wicri:regionArea><wicri:noRegion>Attiki</wicri:noRegion></affiliation></author><author><name>S. Stathaki</name><affiliation wicri:level="1"><mods:affiliation>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki</wicri:regionArea><wicri:noRegion>Attiki</wicri:noRegion></affiliation></author><author><name>C. I. Stassinopoulou</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biology, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biology, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki</wicri:regionArea><wicri:noRegion>Attiki</wicri:noRegion></affiliation></author><author><name>E. Chiotellis</name><affiliation wicri:level="1"><mods:affiliation>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki</wicri:regionArea><wicri:noRegion>Attiki</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1993_Article_BF00169805.pdf</idno><date when="1993">1993</date><idno type="doi">10.1007/BF00169805</idno><idno type="wicri:Area/Main/Corpus">000D28</idno><idno type="wicri:Area/Main/Curation">000D28</idno><idno type="wicri:Area/Main/Exploration">000261</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminothiols</term><term>Indium complexes</term><term>Myocardial imaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. 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I.</namePart><namePart type="family">Stassinopoulou</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Institute of Biology, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</affiliation></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Chiotellis</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Institute of Radioisotopes/Radiodiagnostic Products, N.C.S.R. “Demokritos”, Aghia Paraskevi, Attiki, Greece</affiliation></name><typeOfResource>text</typeOfResource><genre>Original Article</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1992-05-18</dateCreated><dateValid encoding="w3cdtf">2004-07-01</dateValid><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. A system of one six-membered and two five-membered rings, formed by the metal and the donor atoms of the ligand, may constitute a basic structure for the development of new indium tracers with myocardial affinity.</abstract><subject lang="eng"><genre>Key words</genre><topic>Aminothiols</topic><topic>Indium complexes</topic><topic>Myocardial imaging</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1993</partNumber><partNumber>Volume: 20</partNumber><partNumber>Number: 4</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1993-04-01</dateIssued><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 21</identifier><recordInfo><recordOrigin>Springer-Verlag, 1993</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00169805</identifier><identifier type="matrixNumber">Art5</identifier><identifier type="local">BF00169805</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>302</start><end>307</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1993</recordOrigin><recordIdentifier>259_1993_Article_BF00169805.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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